Rupress.org

Breathe—Your immune system is counting on it

WEBThe airway environment is complex, even when considered in a snapshot of time (Olivença et al., 2021).Multiple epithelial cell types contribute to the conductive …

Actived: 6 days ago

URL: https://rupress.org/jem/article/218/4/e20202643/211889/Breathe-Your-immune-system-is-counting-on

The blood–brain barrier in health and disease: Important …

WEBBlood vessels provide the vital infrastructure for delivery of oxygen and essential nutrients throughout the body, and the term “blood–brain barrier” (BBB) is used to describe the …

Category: Health Go Health

Sleep exerts lasting effects on hematopoietic stem cell function …

WEBSleep abundance and quality vary over an individual’s lifespan (Ohayon et al., 2004; Kamel and Gammack, 2006), and the impact of sleep variability on long-term …

Category: Health Go Health

The Z-nucleic acid sensor ZBP1 in health and disease

WEBNucleic acid sensing is a central process in the immune system, with far-reaching roles in antiviral defense, autoinflammation, and cancer. Z-DNA binding protein …

Category: Cancer Go Health

The dark side of the gut: Virome–host interactions in intestinal

WEBThe human gastrointestinal tract harbors diverse populations of bacteria, fungi, archaea, viruses, and eukaryotic microorganisms. This complex community of microbes, …

Category: Health Go Health

Immune system: The “seventh sense”

WEBImmune system: The “seventh sense”. J Exp Med (2018) 215 (2): 397–398. The brain is our computing machine that integrates stimuli from the environment and …

Category: Health Go Health

Toward a better understanding of folate metabolism in health and

WEBHaving learned of the discovery of folic acid, Sidney Farber recruited a cohort of leukemic children to test whether folic acid might be able to restore normalcy to the blood cells in …

Category: Health Go Health

The gut microbiome: Relationships with disease and opportunities …

WEBThrough the application of high-throughput assays, it has become apparent that the healthy human superorganism comprises a series of niche-specific microbiomes across distinct …

Category: Health Go Health

Mitochondria as intracellular signaling platforms in health and …

WEBMitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging as critical hubs for intracellular signaling. Due to their bacterial …

Category: Health Go Health

Mitochondria on the move: Horizontal mitochondrial transfer in …

WEBA prominent feature of mtDNA is its heteroplasmy (more than one mitochondrial genotype) mediated by tissue-specific non-random segregation …

Category: Health Go Health

Bile acids in glucose metabolism in health and disease

WEBBile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling …

Category: Health Go Health

Senescence and aging: Causes, consequences, and therapeutic …

WEBAging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological …

Category: Cancer Go Health

The gut microbiome: Relationships with disease and …

WEBThus, the confluence of data from human and murine studies indicates that the gut microbiome plays a key role in promoting appropri-ate physiological and immune …

Category: Health Go Health

REVIEW The blood brain barrier in health and disease: …

WEBBrain ECs have a denser glycocalyx than peripheral vas-culature; average glycocalyx coverage is 40.1% in brain vessels compared with 15.1% and 3.2% in cardiac and …

Category: Health Go Health

The cell biology of the hepatocyte: A membrane trafficking machine

WEBHepatocytes comprise up to 80% of the total cell population and volume of the human liver and are intimately associated with both arterial and venous blood (Blouin et al., …

Category: Health Go Health

Hongyuan Yang: Tracking lipids, one droplet at a time

WEBMy five-year doctoral study focused entirely on the enzymes Sterol O-Acyltransferases (SOAT, also known as ACAT, Acyl-CoA Cholesterol Acyltransferases), …

Category: Health Go Health

A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED …

WEB1. An efficient generator of focused ultrasound has been designed, built, and successfully operated. 2. The generator has been used to produce focal heating in the centers of …

Category: Health Go Health

Imatinib augments standard malaria combination therapy without …

WEBMalaria remains a serious health problem in much of the world today, with ∼228 million new cases and ∼405,000 deaths estimated in 2018 (World Health …

Category: Health Go Health

Editors and Staff Journal of Experimental Medicine Rockefeller

WEBAssociate Editors Elena Hsieh, Associate Editor. Elena Hsieh earned her MD degree from University of California San Francisco (UCSF) in 2008. She completed a residency in …

Category: Health Go Health

Bile acids in glucose metabolism in health and disease

WEBBile acids in glucose metabolism in health and disease. Hagit Shapiro,* Aleksandra A. Kolodziejczyk,* Daniel Halstuch,* and Eran Elinav. Department of Immunology, …

Category: Health Go Health

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