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The pathogenesis of syphilis: the Great Mimicker, revisited

WebCausative agent. Syphilis is a chronic infectious disease caused by the spirochaete Treponema pallidum subspecies pallidum. The genus Treponema belongs to …

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URL: https://pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.1903

The endocrine system and ageing

WebAbstract. Complex changes occur within the endocrine system of ageing individuals. This article explores the changes that occur in the metabolism and …

Category: Health Go Health

The roles of fascins in health and disease

WebIntroduction: fascin structure, gene family, and evolution. Fascins are globular proteins of approximately 55 kD composed of four tandem fascin domains, each …

Category: Health Go Health

Skin fibroblast functional heterogeneity in health and disease

WebAbstract Fibroblasts are the major cell population of connective tissue, including the skin dermis, and are best known for their function in depositing and …

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The cytoskeleton and disease

WebThe last paper of this review issue is dedicated to septins. Hall and Russell 17 argue convincingly why these proteins, which were discovered in yeast and have …

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The Journal of Pathology

WebThe 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The …

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The pathogenesis of human cytomegalovirus

WebIntroduction. Human cytomegalovirus (HCMV) infects most individuals in the world, usually without producing overt symptoms. It came to medical attention when the …

Category: Medical Go Health

Single‐cell profiling identifies distinct hormonal, immunologic, and

WebSingle-cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis-constituting cells

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Recent Advances in Pathology: the 2020 Annual Review Issue of …

WebThis year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the …

Category: Health Go Health

Recent Advances in Pathology: the 2022 Annual Review Issue of …

WebThe 2022 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing …

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Club‐like cells in proliferative inflammatory atrophy of the prostate

WebClub cells are a type of bronchiolar epithelial cell that serve a protective role in the lung and regenerate damaged lung epithelium. Single-cell RNA sequencing (scRNA …

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The pathology of ageing: concepts and mechanisms

WebPutting together some of the current thinking on age-ing has been a great experience and challenge. This review issue of the Journal of Pathology addresses both cellular and …

Category: Health Go Health

Cancer‐associated fibroblasts potentiate colorectal cancer …

WebColorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression. Cancer …

Category: Cancer Go Health

The systemic influence of chronic smoking on skin structure and

WebOne of the major functions of human skin is to provide protection from the environment. Although we cannot entirely avoid, for example, sun exposure, it is likely …

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PINK1 in the limelight: multiple functions of an eclectic protein in

WebIntroduction. The PINK1 gene was initially identified in 2001 as an up-regulated target of PTEN in endometrial cancer cells 1, but only in 2004 did this gene …

Category: Cancer Go Health

Endometrial carcinoma: molecular subtypes, precursors and the …

WebEndometrial carcinoma (EC) is the most common cancer of the female reproductive organs in the developed world, and the fourth most common cancer in …

Category: Cancer Go Health

Anoikis: an emerging hallmark in health and diseases

WebIntrinsic pathway. In the intrinsic pathway, caspase activation occurs as a consequence of mitochondrial permeabilization due to formation of oligomers in the outer …

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Bone marrow‐derived macrophage contributes to fibrosing …

WebJuqiang Han. Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health …

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Anoikis: an emerging hallmark in health and diseases

WebAbstract. Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in …

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