Naviauxlab.ucsd.edu
Healing and Recovery – Naviaux Lab
WEBThe three stages of the healing cycle are made possible by metabolic patterns that are produced by 3 different kinds of mitochondria. M1 mitochondria are proinflammatory. M0 mitochondria support Warburg metabolism, aerobic glycolysis, and cell growth. M2 mitochondria are anti-inflammatory and tumor suppressing.
Actived: 2 days ago
URL: https://naviauxlab.ucsd.edu/science-item/healing-and-recovery/
Human Health and Ocean Pollution
WEBArt. 151,page 4of64 Landrigan et al: Human Health and Ocean Pollution. By focusing our analysis on human impacts, we under- score the fact that pollution of the oceans poses a clear and present danger to human health. It is causing disease, disability, and premature death in countries around the world today.
About – Naviaux Lab
WEBThe Naviaux Lab at UCSD has a track record of innovation and discovery that has meant real progress for children with mitochondrial disease for 20 years. Research in the Naviaux laboratory is divided in three groups: Mitochondrial Mechanisms of Health and Disease, and Healing. Ecogenetics, Metabolomics, and Environmental Impacts on Child Health.
Environmental Health – Naviaux Lab
WEBThe new research. We studied plankton samples from the North Pacific collected from 2000 to 2020 and stored in the CPR archive in the UK 3.Manmade pollutants like phthalates, plasticizers, pesticides like chlorpyrifos, perfluoroalkyl substances (PFAS, teflons), polycyclic aromatic hydrocarbons (PAH), and antibiotics (including amoxicillin) were …
Depression and Suicide – Naviaux Lab
WEBSuicidal thoughts occur in 90-100% of patients with treatment-resistant depression. About 30% of patients with treatment-resistant depression will attempt suicide. In the past 20 years, the prevalence of depression has been increasing 10% per decade 10, and suicide mortality has increased by 33% since 1999 11.
The 28th Amendment Project – Naviaux Lab
WEBThe Naviaux Lab is seeking help to start a movement to create, refine, and ratify a 28 th Amendment to the Constitution of the United States. This amendment will enunciate a new right for all American citizens. This is “right to be born into a healthy environment”, an environment that will not cause chronic childhood and adult disease.
Mitochondrial Disease research – Naviaux Lab
WEBThe MMDC aims to unify the three essential elements of medical progress: diagnosis, treatment, and research. Our lab was founded in 1994 to help children and adults with mitochondrial disease. Scientists have classified of over 300 different kinds of genetically and clinically distinct mitochondrial disorders1.
Team – Naviaux Lab
WEBRobert K. Naviaux, MD, PhD (. Biosketch. , Bio. ) Dr. Naviaux is a Professor of Genetics, in the Departments of Medicine, Pediatrics, and Pathology. He directs a core laboratory for metabolomics at UCSD. He is the co-founder and a former president of the Mitochondrial Medicine Society (MMS), and a founding associate editor of the journal
Suramin – Naviaux Lab
WEBSuramin. The Naviaux Lab discovered that the unique properties of suramin made it the first in a new class of drugs that could be used to test the cell danger response (CDR) hypothesis for the origin and treatment of autism spectrum disorder (ASD). Suramin successfully improved all the core symptoms of ASD and the metabolic and GI …
Alpers Syndrome research – Naviaux Lab
WEBAlpers syndrome is a devastating genetic disorder that leads to seizures and liver disease in children and young adults. Its cause remained a mystery for nearly 70 years after it was first described in 1931 by Bernard Alpers. Dr. Naviaux’s team at UCSD discovered the cause of this classical mitochondrial disease and developed the first DNA
Metabolic features of the cell danger response
WEBThe cell danger response is coordinated in the brain via chemosensory integration of whole body and microbiome metabolism. Abnormal persistence of the CDR ultimately leads to altered organ func-tion and behavior, and results in chronic disease. Small molecule nutrients and metabolites are the prime movers of the CDR.
Breakthroughs in the Cause and Treatment of Autism and …
WEBOne year of support for a research scientist in Dr. Naviaux’s lab costs $125,000. This includes all the costs for salary, benefits, and research supplies for one PhD, or MD/PhD scientist. Gifts of $500,000 to $1.5 million can help significantly by establishing a program of research with support for 3 or more years.
Metabolic features of chronic fatigue syndrome
WEBAnother metabolic fate of hy-droxyproline is glyoxylate, which can be transaminated in mito-chondria to produce glycine and metabolized in peroxisomes to oxalate and peroxide for cell defense and innate and antiviral immunity (29). Plasma Arg levels were also increased in chronic fatigue males and females.
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