Microbiomejournal.biomedcentral.com
Statistical modeling of gut microbiota for personalized health …
WEBThe gut microbiome is closely associated with health status, and any microbiota dysbiosis could considerably impact the host’s health. In addition, many active consortium projects have generated many reference datasets available for large-scale retrospective research. However, a comprehensive monitoring framework that analyzes …
Actived: 9 days ago
URL: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-023-01614-x
Understanding the host-microbe interactions using metabolic …
WEBThe human gut harbors an enormous number of symbiotic microbes, which is vital for human health. However, interactions within the complex microbiota community and between the microbiota and its host are challenging to elucidate, limiting development in the treatment for a variety of diseases associated with microbiota dysbiosis. Using in …
An integrated gene catalog and over 10,000 metagenome …
WEBBackground Gastrointestinal tract (GIT) microbiomes in ruminants play major roles in host health and thus animal production. However, we lack an integrated understanding of microbial community structure and function as prior studies are predominantly biased towards the rumen. In this study, we used shotgun metagenomics …
Proteobacteria explain significant functional variability in the …
WEBTo describe variation within healthy gut microbiota across different human populations, we randomly selected 123 metagenomes of healthy individuals from the Human Microbiome Project (HMP, n=42) [], controls in a study of type II diabetes (T2D, n=44) [], and controls in a study of glucose control (GC, n=37) [].These span American, …
Research on the human virome: where are we and what is next
WEBThe National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened a Working Group on the Microbiome in Cardiovascular, Pulmonary and Hematologic Health and Diseases from June 25, 2014, to June 26, 2014. The Working Group’s central goal was to define what major microbiome research areas …
Early life inter-kingdom interactions shape the immunological
WEBThere is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are involved in this process, there is a knowledge gap concerning the role of fungi. Moreover, the inter-kingdom interactions …
Changes of the human skin microbiota upon chronic exposure to
WEBPolycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns and contribute to adverse skin attributes such as premature skin aging and pigmentary disorder. However, little information is available on the potential roles of chronic urban PAH pollutant exposure on the cutaneous microbiota. Given the roles of the skin …
Challenges in exploring and manipulating the human skin …
WEBThe skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and …
Gut microbes exacerbate systemic inflammation and behavior …
WEBCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in NOTCH3. The clinical manifestations are influenced by genetic and environmental factors that may include gut microbiome. We investigated the fecal metagenome, fecal …
Cleanliness in context: reconciling hygiene with a modern …
WEBThe concept of hygiene is rooted in the relationship between cleanliness and the maintenance of good health. Since the widespread acceptance of the germ theory of disease, hygiene has become increasingly conflated with sterilization. In reviewing studies across the hygiene literature (most often hand hygiene), we found that nearly all studies …
Longitudinal multi-omics analysis uncovers the altered landscape …
WEBBackground Gut microbiota is significantly influenced by altitude. However, the dynamics of gut microbiota in relation to altitude remains undisclosed. Methods In this study, we investigated the microbiome profile of 610 healthy young men from three different places in China, grouped by altitude, duration of residence, and ethnicity. We conducted …
Reduced B12 uptake and increased gastrointestinal formate are
WEBMethane is an end product of microbial fermentation in the human gastrointestinal tract. This gas is solely produced by an archaeal subpopulation of the human microbiome. Increased methane production has been associated with abdominal pain, bloating, constipation, IBD, CRC or other conditions. Twenty percent of the …
Functional changes in the oral microbiome after use of fluoride …
WEBCaries is a multi-factorial disease caused by microbial-derived acidic pH, which demineralizes the enamel [].It is considered one of the most widespread diseases worldwide, and efficient tooth brushing with a fluoride dentifrice is fundamental to caries prevention [2,3,4,5].Several microbiological studies have proven a direct role for oral …
Gut microbiota-derived 3-phenylpropionic acid promotes …
WEBBackground The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function. The mining of the gut microbes that facilitate the function of intestinal epithelial barrier is urgently needed. …
Direct impact of commonly used dietary emulsifiers on human gut
WEBSeveral dietary emulsifiers impact microbiota density in the MBRA model. Two widely used synthetic dietary emulsifiers, CMC and P80, directly alter the composition and gene expression of human microbiota in vitro, in doses ranging from 0.10 to 1.00%, recapitulating their actions in vivo in animal models [5, 11].We sought to investigate if …
Dissecting the factors shaping fish skin microbiomes in a …
WEBBackground Fish skin microbiomes are rarely studied in inland water systems, in spite of their importance for fish health and ecology. This is mainly because fish species distribution often covaries with other biotic and abiotic factors, complicating the study design. We tackled this issue in the northern part of the Jordan River system, in …
Rhizosphere protists are key determinants of plant health
WEBPlant pathogens can colonize the rhizosphere and have a severe influence on plant health [1, 2].However, pathogen success and plant health are ultimately controlled by other biota, particularly the rhizosphere microbiome [3, 4].The plant rhizosphere microbiome is a complex assembly of diverse microorganisms, including bacteria, fungi, and protists …
Fecal metagenomic profiles in subgroups of patients with …
WEBRESEARCH Open Access Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/ chronic fatigue syndrome Dorottya Nagy-Szakal1†, Brent L. Williams1†, Nischay Mishra1, Xiaoyu Che1, Bohyun Lee1, Lucinda Bateman2, Nancy G. Klimas3,9, Anthony L. Komaroff4, Susan Levine5, Jose G. Montoya6, Daniel L. …
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