Loyalfordogs.com
About Us loyalfordogs.com
WebOur mission is to help dogs everywhere live longer, healthier lives. Loyal is a clinical-stage veterinary medicine company developing drugs intended to extend the healthspan and lifespan of dogs. Melo. Australian Shepherd.
Actived: Just Now
Loyal’s latest milestone: the first longevity clinical study design
WebAt Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters. On the path to FDA approval, we must run a clinical trial that objectively and robustly demonstrates that our drug extends dogs’ healthy lifespan, and does so safely. Because …
Our LOY-002 clinical pilot study is now fully enrolled
WebWe’ve now fully enrolled our first clinical study for LOY-002 — the internal name for our daily tablet intended to extend lifespan and quality of life for older dogs. Sixty companion dogs — from 7 to 10 years old, and weighing from 14 to 180 pounds — are participating to help us better understand LOY-002’s impact on how dogs age.
How scientists measure aging through Healthspan, frailty and
Webby Brennen McKenzie, MA, MSc, VMD. Loyal has just published the results of our Healthspan study, the first clinical study assessing two tools for measuring frailty and health-related quality of life in dogs. Dogs are a unique translational model of aging. By understanding aging in dogs, we learn how to better treat aging in both dogs and humans.
What is DNA methylation and how does it help us understand
WebWe are currently researching this here at Loyal, and we believe that this relationship is a clue that will help us to unlock longer healthier lives for dogs and humans. Jumbo. DNA methylation is a useful tool for assessing health and longevity—both in dogs and humans. Loyal scientists are studying aging through the lens of DNA methylation and
How old is your dog, really
WebBased on information from the shelter, Abigail estimates that Mazel was born in August 2009, but she’d always suspected he was older. When she swabbed Mazel earlier this year for XTD, Mazel’s methylation age was 9 months younger than his reported age. The model suggests Mazel’s age is closer to 12 years and 3 months.
Helping dogs live longer, healthier lives loyalfordogs.com
WebWe’ve launched a major new clinical study for LOY‑002, our drug to extend lifespan and maintain quality of life in senior dogs of nearly all sizes. We’re enrolling 1,000 senior dogs at 55 veterinary clinics across the country. See if your dog qualifies to participate.
Healthspan: the healthy prime of life
WebHealthspan is the period of life where they are living full, healthy lives, before any major illness or functional decline. The figure below shows different possible trajectories for a dog’s life. Increasing healthspan means giving dogs more time in good health. A treatment that extends healthspan can slow age-related decline in health and
You and your dog share similarities in your blood: Exploring …
WebThe Loyal team conducted two studies to evaluate potential biomarkers in dogs. Both of these studies looked at the blood of old and young dogs to determine if any specific age-dependent changes could point to a potential biomarker. We found a number of markers at the cellular and protein levels that change in an age-dependent manner.
How movement and exercise in dogs promotes longevity and
WebIn the meantime, consider indoor cognitive enrichment activities to occupy your dog and help improve their brain aging. It is well established that exercise has health benefits in humans. Regular physical activity can extend lifespan, reduce the occurrence of age-associated diseases, and help maintain and restore function in humans.
The power of big datasets
WebAs part of our research to understand canine aging, Loyal has collaborated with Banfield Pet Hospital, the leading provider of preventive veterinary care in the United States, to analyze the electronic health records (EHRs) of 131,140 dogs spanning 20 years of care.. The power of large, longitudinal datasets. Banfield’s dataset is remarkably …
Clinical Trials loyalfordogs.com
WebWe’re helping dogs like yours live longer. Loyal is recruiting senior dogs to be part of our STAY study — the final effectiveness study for LOY-002, our medication to help dogs live longer and stay healthier as they age. Sign up for the STAY study. The launch of the STAY study is a major step toward making LOY-002 available to dogs everywhere.
$125M to extend dog lifespan
WebEach participant in the X-Thousand Dogs Study will receive a report with information about their dog’s ancestry. In this post, Loyal’s Dr. John Lindo, who specializes in ancient DNA and canine evolution, explains how our understanding of the relationships between species has changed over time and what a DNA test can—and cannot—reveal …
Meet Boo — the first dog dosed in our LOY-002 pivotal study for
WebOur recent announcement about LOY-001 — our drug to extend healthy lifespan in large-breed dogs — prompted an incredible amount of press coverage and conversation, including a shoutout at the Emmy awards. We’ve been touched by how enthusiastic the response has been to our work. With LOY-001’s focus on large dogs, …
For Veterinarians loyalfordogs.com
WebA veterinary clinical trial is a research study conducted on veterinary patients and designed to determine whether a new medical, surgical, or behavioral intervention is safe and effective. Although veterinary clinical trials only enroll veterinary patients, the results often have impacts for both veterinary and human medicine.
Introducing X-Thousand Dogs
WebYesterday we launched X-Thousand Dogs, the largest dog epigenetics study in the world, powered by the participation of science-minded dog lovers.And thanks to the overwhelming response, the DNA sampling portion of the study is already fully subscribed. There’s still time to play an important role, however, by joining the interactive community …
Why do big dogs have unusually short lifespans compared to
WebIt is not completely clear why large dog breeds have shorter lifespan than small dog breeds. One possibility is that they may age faster, accumulating physiologic abnormalities and health problems sooner than smaller dogs. Alternatively, they may experience the same overall health impacts of aging as smaller breeds but be less able …
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