Bmcsystbiol.biomedcentral.com

Systems healthcare: a holistic paradigm for tomorrow

WebSystems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, …

Actived: 7 days ago

URL: https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0521-2.pdf

New perspectives: systems medicine in cardiovascular disease

WebBackground Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to …

Category: Health Go Health

Towards understanding brain-gut-microbiome connections in …

WebAlzheimer’s disease (AD) is complex, with genetic, epigenetic, and environmental factors contributing to disease susceptibility and progression. While …

Category: Health Go Health

A General Life History Theory for Effects of Caloric Restriction on

WebMetabolic rate and body temperature. Over ontogeny, the resting metabolic rate, B rest, scales with body mass, m, as B rest = B 0 m 3/4, where B 0 is a …

Category: Health Go Health

Multilevel modeling and value of information in clinical trial …

WebClinical trials are the main method for evaluating safety and efficacy of medical interventions and have produced many advances in improving human health. …

Category: Medical Go Health

Model-based clustering reveals vitamin D dependent multi …

WebNutritional systems biology is an emerging field that aims to characterize the molecular link between diet and health in an integrated fashion [].Interactome models, in …

Category: Nutrition Go Health

RNF14 is a regulator of mitochondrial and immune function in …

WebMuscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in …

Category: Health Go Health

A community effort towards a knowledge-base and mathematical …

WebThe evolution of antibiotic resistance by a variety of human pathogens is a looming public health threat [1, 2].Salmonella is a major human pathogen and a model …

Category: Health Go Health

A computational framework for complex disease stratification from

WebMultilevel data integration is becoming a major area of research in systems biology. Within this area, multi-‘omics datasets on complex diseases are becoming more …

Category: Health Go Health

The evolution of metabolic networks of E. coli BMC Systems …

WebBackground Despite the availability of numerous complete genome sequences from E. coli strains, published genome-scale metabolic models exist only for …

Category: Health Go Health

GNE: a deep learning framework for gene network inference by

WebA comprehensive study of gene interactions (GIs) provides means to identify the functional relationship between genes and their corresponding products, as well as …

Category: Health Go Health

Systems biology as an emerging paradigm in transfusion medicine

WebBlood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of …

Category: Medicine Go Health

Estimating drivers of cell state transitions using gene regulatory

WebSpecific cellular states are often associated with distinct gene expression patterns. These states are plastic, changing during development, or in the transition from …

Category: Health Go Health

Microbial community pattern detection in human body habitats …

WebThe human habitat is a host where microbial species evolve, function, and continue to evolve. Elucidating how microbial communities respond to human habitats is …

Category: Health Go Health

A review of imaging techniques for systems biology

WebThis paper presents a review of imaging techniques and of their utility in system biology. During the last decade systems biology has matured into a distinct field …

Category: Health Go Health

Linking physiologically-based pharmacokinetic and genome-scale

WebEstrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both …

Category: Health Go Health

Physiological fidelity or model parsimony

WebBackground Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, …

Category: Health Go Health