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Patient Health-Disease Continuum

WEBA patient’s stage of disease progression is classified within a disease-health continuum using patient history, physical examination, and laboratory parameters including …

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URL: https://www.bioregulatory-systems-medicine.com/en/brsm-model/patient-health-disease-continuum

The Bioregulatory Systems Medicine Model

WEBThe BrSM model represents a consensus understanding of the core elements fundamental to Bioregulatory Systems Medicine and the unique relationships between those …

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Autoregulation of Biological Networks

WEBAutoregulation is an inherent feature of regulatory networks. At the biochemical level, at least three types of molecular networks (metabolite, protein, and gene) are …

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From Systems Biology to Bioregulatory Systems Medicine

WEBFrom Systems Biology to Bioregulatory Systems Medicine. Since the early 2000s, scientific communities around the globe have been driven by the revolutionary insights garnered …

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Bioregulatory Clinical Pharmacology

WEBThe BrSM model proposes wider use of multitarget medications rather than more exclusive reliance on single-target drugs. A fundamental principle of bioregulatory clinical …

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Microenvironment Response to Inflammation

WEBThe microenvironment is directly involved in the initiation and resolution of inflammatory responses. Chronic inflammation is associated with most age-related diseases including …

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Biological Communication at the Microenvironment-Scale

WEBThe microenvironment is a critical supporter of healthy cells and the conduit of biological information in tissues. A healthy microenvironment includes the biochemical and …

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Inflammation Physiology

WEBInflammation that is caused by stressed, apoptotic cells or metabolic changes acts as an extension of the autoregulatory capacity of the organism and helps to maintain and/or …

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Diagnostics and Therapeutic Strategy

WEBThree principles guide the therapeutic approach in Bioregulatory Systems Medicine: The autoregulatory network is the primary therapeutic target instead of the trigger or the …

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Clinical Focus on Dysregulation

WEBApplication of BrSM in clinical practice focuses on identifying dysregulated autoregulatory networks. In diseases where a stressor and a dysregulated network are engaged in a …

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Clinical Application Model

WEBBioregulatory Systems Medicine Conceptual Clinical Application Model. The model depicted in this figure represents three integrated levels as part of a single, unified entity.

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The BrSM initiative

WEBThe BrSM Initiative was launched in 2008 through an initial meeting of global medical experts in collaboration with experts in bioregulatory medicine from Heel. The team set …

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Developing the BrSM model

WEBDeveloping the BrSM model. In 2008, Heel convened the initial model development meeting with independent medical and scientific experts, in collaboration with experts in …

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Download the whitepaper

WEBDownload the BrSM White Paper for free. Please complete the form below in order to download the White Paper. Asterisk (*) indicate fields required to complete this

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Biological Communication across Multi-Scale Networks

WEBLinear model versus non-linear causation model. The fields of molecular biology and medicine have traditionally considered influence and causality among relevant entities …

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Group Concept Mapping

WEBBased on a group concept mapping process, individual inputs were analyzed in order to establish relationships among the items drafted from literature review and expert …

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Conceptual approach

WEBConceptual approach. BrSM offers an expansion to the current medical approach that broadens the clinical toolbox. The realization of the fundamental interconnectedness of …

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