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Protein Instability and Lou Gehrig's Disease

WEBMarch 25, 2015. A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s …

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URL: https://als.lbl.gov/protein-instability-and-lou-gehrigs-disease/

A Citizen-Science Computer Game for Protein Design

WEBThe user interface of Foldit, a free online computer game developed to crowdsource problems in protein modeling. (a) The Foldit score: better models yield higher scores. (b) …

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The Effects of Diabetes on Spinal-Column Biomechanics

WEBThe Effects of Diabetes on Spinal-Column Biomechanics. February 26, 2024. Worldwide, the prevalence of diabetes is increasing, leading to a growing global burden in health …

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Two Basic Mechanisms of Cardiovascular Drugs

WEBThe structures of proteins controlling calcium-ion transport through cell membranes have been revealed, bound to two drugs known as calcium channel blockers. The discovery …

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Targeting Bacteria That Cause Meningitis and Sepsis

WEBMeningococcal disease. Our central nervous systems (brain and spinal cord) are surrounded by three membranes called “meninges.”. Meningitis is caused by the …

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How Proteins Remodel DNA in Bacteria under Stress

WEBIn bacteria, the proteins responsible for DNA packing are called HU proteins. They are dimers—made up of two identical or nearly identical subunits that, when joined, form a …

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8.3.1 Quick Reference

WEBQuick Reference. How do I acknowledge beamline 8.3.1 in my paper? Beamline 8.3.1 at the Advanced Light Source is operated by the University of California at San Francisco with …

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An Antibody That Broadly Neutralizes SARS-CoV-2

WEBAn antibody that appears to neutralize all known SARS-CoV-2 strains and closely related coronaviruses was discovered with the help of the ALS. The work highlights principles …

Category:  Coronavirus Go Health

Mapping the Topology of the Human Genome

WEBMapping the Topology of the Human Genome. July 11, 2016. Department of Energy facilities such as the Joint Genome Institute provide us with DNA sequences for entire …

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Jim Floyd, Environment, Health and Safety

WEBThe Lab’s Environment, Health and Safety Division continues to reach out to the research community for ideas on how to improve its policies and processes. Many staff at the ALS …

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Antibody Uses Mimicry to Block SARS Coronavirus

WEBTo invade a cell, the SARS coronavirus (SARS-CoV) must fuse with the membrane of a host cell. Normally, this fusion is facilitated by the binding of ACE2 receptors (teal) to the …

Category:  Coronavirus Go Health

Structure of a Key Protein from the Zika Virus

WEBThe Zika virus (ZIKV) is a mosquito-borne pathogen recently linked to birth defects in infants. At the ALS, researchers have resolved the structure of a key ZIKV protein to 3.0 …

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Crystal Misorientation Toughens Human Tooth Enamel

WEBThe enamel that covers the exposed surface of human teeth is the hardest tissue in the human body. Incredibly, this protective layer enables our teeth to last a lifetime. In …

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Experiment Safety

WEBSafety at the ALS. Safety is a core value that helps support the mission of the ALS, which is to “advance science for the benefit of society by providing our world-class synchrotron …

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Breakthrough in Membrane-Protein Design Settles Long-Standing …

WEBA long-standing debate among scientists is whether van der Waals forces—short-range forces between uncharged molecules—are too weak to stabilize large, complex, three …

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Molecular Switch Triggers Bacterial Pathogenicity

WEBScientists have revealed for the first time the molecular steps that turn on bacteria’s pathogenic genes. Using an array of high-powered x-ray imaging techniques at the ALS, …

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Experimental Drug Targets HIV in a Novel Way

WEBA drug with a novel mechanism of action. Most HIV drugs work by blocking viral enzymes—proteins that initiate key steps in the viral life cycle. In contrast, GS‑6207 …

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Guiding Target Selection for COVID-19 Antibody Therapeutics

WEBProtein-structure studies helped demonstrate that the primary target of antibody-based COVID-19 immunity is the part of the virus’s spike protein that can most easily mutate. …

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